Dry matter yield and nutrient removal information is critical for the development of nutrient management plans to optimize productivity and environmental conservation goals. Sorghum cultivars ES5200 and M81-E were evaluated for four years in North Carolina in experimental areas located at a research station and also on-farm. Dry matter yield of sorghum ES5200 was greatest at a N fertilization rate of 67 kg per hectare with no significant increase of dry matter yield production beyond this N rate. There was no N fertilization rate effects for dry matter yield response of sorghum M81-E. Both sorghum cultivars were productive biomass crops at swine spray fields and may be a feasible alternative for producers that desire the flexibility of an annual crop and high biomass yields (~16 Mg per hectare) in a single clipping at the end of the growing season; however, nutrient loadings will need to be less intensive (lower amounts) compared to current bermudagrass-based systems to comply with NC nutrient management plan guidelines.